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Case of NDM-1 Carbapenemase-producing Enterobacteriaceae under CHP investigation
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     The Public Health Laboratory Services Branch (PHLSB) of the Centre for Health Protection (CHP) of the Department of Health confirmed today (June 10) a case of New Delhi metallo-]-lactamase-1 (NDM-1) Carbapenemase-producing Enterobacteriaceae affecting an 8-month-old baby girl.

     The patient, with underlying illness, had been hospitalised in India after birth and came to Hong Kong in November 2013. She developed cough, shortness of breath and vomiting since May 26 and was admitted to a private hospital on June 1. She has been in stable condition all along and was discharged on June 4.

     The patient's urine sample yielded NDM-1 Carbapenemase-producing Enterobacteriaceae as confirmed by the PHLSB. Her home contacts are asymptomatic.

     The CHP's investigations are ongoing.

     This is the 47th detected case of NDM Carbapenemase-producing Enterobacteriaceae in Hong Kong.

     NDM is an enzyme which can inactivate carbapenems and other beta-lactams such as penicillins. Bacteria harbouring this NDM gene are commonly resistant to multiple antimicrobials, limiting therapeutic options and rendering severe clinical infections difficult to treat. Most bacteria with the NDM enzyme remain susceptible to two types of antibiotics, colistin and tigecycline.

     Infections vary from being asymptomatic to potentially life-threatening or fatal. The level of risk depends on which part of the body is affected by the infection, and the general health of the patient.

     NDM-producing Enterobacteriaceae was first reported in a Swedish patient of Indian origin who travelled to New Delhi, India, in 2008. The first fatal case was identified in 2010 in a patient who received medical treatment in Pakistan before being repatriated to Belgium.

     NDM-producing Enterobacteriaceae has now been reported in many countries and regions including Australia, Austria, Canada, Belgium, France, Germany, Japan, the Netherlands, Norway, Oman, Sweden, Singapore, Taiwan, the UK and the US. Most patients had prior hospital contact in the Indian subcontinent.

     A CHP spokesman said that proper use of antibiotics and personal hygiene, especially hand hygiene, are important for the prevention of emergence and cross-transmission of NDM strains.

Ends/Tuesday, June 10, 2014
Issued at HKT 16:40

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